72. A topologically chiral catenane that is not topologically chiral
Noel Pairault, Federica Rizzi, David Lozano, Graham J. Tizzard, Stephen M. Goldup,* 2022, ChemRXiv Preprint.

 

71. A Chiral Macrocycle for the Synthesis of Both Mechanically Planar Chiral Rotaxanes and Catenanes in Excellent Enantiopurity
Shu Zhang, Arnau Rodríguez-Rubio, Abed Saady, Graham J. Tizzard, Stephen M. Goldup,* 2022, ChemRXiv Preprint.

 

70. A Co-conformationally “Topologically” Chiral Catenane
Arnau Rodríguez-Rubio, Andrea Savoini, Florian Modicom, Patrick Butler, Stephen M. Goldup,* J. Am. Chem. Soc. 2022, 144, 11927. (ChemRXiv Preprint).

 

69. Mechanically axially chiral catenanes and noncanonical chiral rotaxanes
John R. J. Maynard, Pater Gallagher, David Lozano, Patrick Butler, Stephen M. Goldup,* Nat. Chem. 2022, 14, 1038
(ChemRXiv Preprint).

 

68. Anion-pi Catalysis Enabled by the Mechanical Bond
John R. J. Maynard, Bartomeu Galmés, Athanasios D. Stergiou, Mark D. Symes, Antonio Frontera,* Stephen M. Goldup,* Angew. Chem. Int. Ed. 2022, 61, e202115961
(ChemRXiv Preprint).

67. Controlling catalyst activity, chemo- and stereo-selectivity with the mechanical bond
Andrew W. Heard, Jorge Meijide Suárez, and Stephen M. Goldup,* Nat. Rev. Chem. 2022, 6, 182.

 

66. A Chiral Interlocking Auxiliary Strategy for the Synthesis of Mechanically Planar Chiral Rotaxanes
Alberto de Juan, David Lozano, Andrew Heard, Michael Jinks, Jorge Meijide Suarez, Graham J. Tizzard, Stephen Goldup,* Nature Chem. 2022, 14, 179
(ChemRxiv preprint).

 

65. Spin-Labelled Mechanically Interlocked Molecules as Models for the Interpretation of Biradical EPR Spectra
Lorenzo Gualandi, Paola Franchi, Elisabetta Mezzina, Stephen M. Goldup,* Marco Lucarini,* Chem. Sci. 2021, 12, 8385
(ChemRxiv preprint).

 

64. Rotaxane CoII Complexes as Field-Induced Single-Ion Magnets
Cirulli, Enrico Salvadori, Zhi-Hui Zhang, Michael Dommett, Floriana Tuna, Heiko Bamberger, James Lewis, Amanpreet Kaur, Graham Tizzard, Joris van Slageren, Rachel Crespo Otero,* Stephen M. Goldup,* Maxie Roessler* Angew. Chem. Int. Ed. 2021, 60, 16051.
(ChemRxiv preprint).

 

63. Damming a Molecular Energy Reservoir: Ion-regulated Electronic Energy Shuttling in a [2]Rotaxane
Arkady Kurpryakov, James Lewis, Vicente Martí-Centelles, Stephen Goldup,* Jean-Luc Pozzo, Gediminas Jonusauskas, Nathan McClenaghan* Chem. Sci. 2021, 12, 9196
(ChemRxiv preprint).

 

62. Using the Mechanical Bond to Tune the Performance of a Thermally Activated Delayed Fluorescence Emitter

Pachaiyappan Rajamalli, Federica Rizzi, Wenbo Li, Michael Jinks, Abhishek Kumar Gupta, Beth Laidlaw, Ifor Samuel,* Thomas Penfold,* Steve Goldup,* Eli Zysman-Colman* Angew. Chem. Int. Ed. 2021, 60, 12066.
(ChemRxiv preprint).

 

61. Strategies for the Synthesis of Enantiopure Mechanically Chiral Molecules
John R. J. Maynard, Stephen M. Goldup,* Chem 2020, 6, 1914.

 

60. Vibrational Circular Dichroism Spectroscopy for Probing the Expression of Chirality in Mechanically Planar Chiral Rotaxanes
Mark Antonius Johannes Koenis, Chima Chibueze, Michael Jinks, Valentin Nicu, Lucas Visscher, Stephen M. Goldup,* Wybren Jan Buma,* Chem. Sci. 2020, 11, 8469.

 

59. Rotaxanation as a sequestering template to preclude incidental metal insertion in complex oligochromophores
Huynh Thien Ngo,* James E. M. Lewis, Daniel T. Payne, Francis D'Souza, Jonathan P. Hill, Katsuhiko Ariga, Genki Yoshikawa, Stephen M. Goldup, Chem. Commun. 2020, 56, 7447.

 

58. AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
Amanda Acevedo-Jake, Andrew T. Ball, Marzia Galli, Mikiembo Kukwikila, Mathieu Denis, Daniel G. Singleton, Ali Tavassoli,* Stephen M. Goldup,* J. Am. Chem. Soc. 2020, 142, 5985
(ChemRrxiv preprint).

 

57. Simplicity in the Design, Operation and Applications of Mechanically Interlocked Molecular Machines
Andrew W. Heard, Stephen M. Goldup,* ACS Cent. Sci. 2020,  6, 117.

 

56. Rotaxane Pt(II)-complexes: mechanical bonding for chemically robust luminophores and stimuli responsive behaviour
Zhihui Zhang, Graham J. Tizzard, J .A. Gareth Williams,* Stephen M. Goldup,* Chem. Sci. 2020, 11, 1839.

 

55. A Mechanically Planar Chiral Rotaxane Ligand for Enantioselective Catalysis
Andrew W. Heard, Stephen M. Goldup,* Chem 2020, 6, 1914 (
ChemRxiv preprint)

HIghlighted by Laura Howes in Chemical and Engineering News (click here), Matteo Zanda as a Synform article (click here) and on Science Daily (click here)

 

54. Chirality makes a move
Ellen M. G. Jamieson, Stephen M. Goldup,* Nature Chem. (N&V) 2019, 765.

 

53. An Auxiliary Approach for the Stereoselective Synthesis of Topologically Chiral Catenanes
Mathieu Denis, James E. M. Lewis, Florian Modicom, Stephen M. Goldup,* Chem. 2019, 5, 1357.

Highlighted by Laura Howes in Chemistry and Engineering News (C&E News 2019, 97) and as one of 6 selected papers on Supramolecular Chemistry by Dr Robert Eagling, Editor in Chief of Cell press (see @Chem_CP)

 

52. Chemical Consequences of the Mechanical Bond: A Tandem Active Template-Rearrangement Reaction
Florian Modicom, Ellen M. G. Jamieson, Elise Rochette, and Stephen M. Goldup,* Angew. Chem. Int. Ed. 2019, 58, 3875.

Highlighted by Tim Swager and Jesica Beard in Synfacts (Synfacts, 2019, 15, 0252).

 

51. Rotaxane-Based Transition Metal Complexes: Effect of the Mechanical Bond on Structure and Electronic Properties
Martina Cirulli, Amanpreet Kaur, James E. M. Lewis, Zhihui Zhang, Jonathan A. Kitchen, Stephen M. Goldup,* and Maxie M. Roessler,* J. Am. Chem. Soc. 2018, 141, 879.

 

 

50. Stereoselective Synthesis of Mechanically Planar Chiral Rotaxanes
Michael A. Jinks, Alberto de Juan, Mathieu Denis, Catherine J. Fletcher, Marzia Galli, Ellen M. G. Jamieson, Florian Modicom, Zhihui Zhang, and Stephen M. Goldup,* Angew. Chem. Int. Ed. 2018, 57, 14806.

Highlighted in Science by Jake Yeston (Science 2018, 301)

 

49. Molecular Machines Swap Rings (Invited N&V)
Stephen M. Goldup,* Nature 2018, 557, 39.

 

48. Chirality in Rotaxanes and Catenanes
Ellen M. G. Jamieson, Florian Modicom, Stephen M. Goldup,* Chem. Soc. Rev. 2018, 47, 5266.

 

47. A [3]Rotaxane Host Selects Between Stereoisomers (Invited highlight)
Mathieu Denis, Stephen M. Goldup,* Angew. Chem. Int. Ed 2018, 57, 4462.

 

46. Efficient Multi-Component Active Template Synthesis of Catenanes
James E. M. Lewis, Florian Modicom, Stephen M. Goldup,* J. Am. Chem. Soc. 2018, 140, 4787.

 

45. Chelating Rotaxane Ligands as Fluorescent Metal Ion Sensors
Mathieu Denis, Jessica Pancholi, Kajally Jobe, Michael Watkinson,* Stephen M. Goldup,* Angew. Chem. Int. Ed. 2018, 57, 5310.

 

44. A Fluorescent Ditopic Rotaxane Ion-Pair Host
Mathieu Denis, Lei Qin, Peter Turner, Katrina A. Jolliffe,* Stephen M. Goldup,* Angew. Chem. Int. Ed. 2018, 57, 5315.

Selected as a Hot Paper.

43. Synthesis and Characterisation of a Paramagnetic [2]Rotaxane Based on a Crown Ether-Like Wheel Incorporating a Nitroxide Motif
Valentina Bleve, Paola Franchi, Evangelia Konstanteli, Lorenzo Gualandi, Stephen M. Goldup, Elisabetta Mezzina,* Marco Lucarini,* Chem. Eur. J. 2018, 24, 1198.

Hydrobromination

 

42. Porphyrinoid Rotaxanes: Building a Mechanical Picket Fence
T. H. Ngo,* J. Labuta, G. N. Lim, W. A. Webre, F. D’Souza,* P. A. Karr, J. E. M. Lewis, J. P. Hill, K. Ariga, S. M. Goldup,* Chem. Sci. 2017, 8, 6679.

Hydrobromination

 

41. The Active Template Approach to Interlocked Molecules
Mathieu Denis and Stephen M. Goldup,* Nat. Rev. Chem. 2017, 61.

Cover article.

 

40. Metal ions in the synthesis of interlocked molecules and materials
James E. M. Lewis, Paul D. Beer, Stephen J. Loeb and Stephen M. Goldup,* Chem. Soc. Rev. 2017, 46, 2577.

Hydrobromination

39. Stepwise, Protecting Group Free Synthesis of [4]Rotaxanes
James E. M. Lewis, Joby Winn and Stephen M. Goldup,* Molecules 2017, 22, 89.

Hydrobromination

 

38. Properties and Emerging Applications of Mechanically Interlocked Ligands
James E. M. Lewis, Marzia Galli, Stephen M. Goldup,* Chem. Commun. 2017, 53, 298.

Hydrobromination

 

37. Iterative Synthesis of Oligo[n]Rotaxanes in Excellent Yield
James E. M. Lewis, Joby Winn, Luca Cera, Stephen M. Goldup,* J. Am. Chem. Soc. 2016, 138, 16329.

Hydrobromination

Cover article. Highlighted in Synfacts by Timothy Swager and Constantin-Christian Voll (Synfacts 2017, 13, 0145) and Bethany Halford in C&E News (Chem. Eng. News. 2016, 94, 8).

 

36. A Kinetic Self-Sorting Approach to Heterocircuit [3]Rotaxanes
Edward A. Neal, Stephen M. Goldup,* Angew. Chem. Int. Ed 2016, 55, 12488.

Hydrobromination

 

35. A chiral catalyst with a ring to it
Stephen M. Goldup,* Nature Chem. N&V Article 2016, 404.

Nature Chem N&V

 

Invited News and Views Article discussing the application of mechanical point chirality in catalysis

34. Scalable Anti-Markovnikov Hydrobromination of Aliphatic and Aromatic Olefins
Marzia Galli, Catherine J. Fletcher, Marc del Pozo, Stephen M. Goldup,* Org. Biomol. Chem. 2016, 14, 5622.

Hydrobromination

 

33. High Yielding Synthesis of 2,2`-Bipyridine Macrocycles, Versatile Intermediates in the Synthesis of Rotaxanes
J. E. M. Lewis, R. J. Bordoli, M. Denis, C. J. Fletcher, M. Galli, E. A. Neal, E. M. Rochette, S. M. Goldup,* Chem. Sci. 2016, 7, 3154.

macrocycles

 

32. Engaging Copper(III) Corrole as an Electron Acceptor: Photoinduced Charge Separation in Zinc Porphyrin-Copper Corrole Donor-Acceptor Conjugates
T. H. Ngo,* David Zieba, W. A. Webre, G. N. Lim, P. A. Karr, S. Kord, S. Jin, K. Ariga, M. Galli, S. M. Goldup, J. P. Hill,* F. D'Souza,* Chem. Eur. J. 2016, 22, 1301.

click porphyrins
Cover article.

 

31. A Stimuli Responsive Rotaxane-Au Catalyst: Regulation of Activity and Diastereoselectivity (open access)
M. Galli, J. E. M. Lewis, S. M. Goldup,* Angew. Chem. Int. Ed. 2015, 54, 13545.

Rotaxane gold catalyst
Highlighted in Nature Chemistry by Ai-Lan Lee ("Supramolecular catalysis: A rotaxane with the golden touch")

 

30. Photodegradation of Rhodamine B over Ag modified ferroelectric BaTiO3 under simulated solar light: pathways and mechanism
Y. Cui, S. M. Goldup, S. Dunn,* RSC Adv. 2015, 5, 30372.

Rhodamine

 

29. Competitive formation of homocircuit [3]rotaxanes in synthetically useful yields in the bipyridine-mediated active template CuAAC reaction (open access)
E. A. Neal, S. M. Goldup,* Chem. Sci. 2015, 6, 2398.

2 vs 3 rotaxanes

 

28. Two Steps Uphill
S. M. Goldup,* Nature Nano. 2015, 10, 488.

Rhodamine

Invited News and Views Article discussing a new molecular machine from the Stoddart Group

27. Selective and general exhaustive cross-coupling of di-chloroarenes with a deficit of nucleophiles mediated by a Pd-NHC complex
B. J. Groombridge, S. M. Goldup,* I. Larrosa,* Chem. Commun. 2015, 51, 3832.

Ipent selectivity

 

26. Biologically Targeted Probes for Zn2+: A Diversity Oriented Modular "Click-SNAr-Click" Approach (open access)
J. Pancholi, D. J. Hodson, K. Jobe, G. A. Rutter,* S. M. Goldup,* M. Watkinson,* Chem. Sci. 2014, 5, 3528.

Targeted Sensors for Zinc

 

25. An Efficient Approach to Mechanically Planar Chiral Rotaxanes (open access)
R. Bordolli, S. M. Goldup,* J. Am. Chem. Soc. 2014, 136, 4817.

Mechanically Chiral Rotaxanes

Highlighted in Chemistry World by Andy Extance ("Rotaxanes make symmetry history") and Nature Nanotechnology by Emilie Moulin & Nicolas Giuseppone ("Chiral mechanical bonds: A move in the right direction")

 

24. Chemical consequences of mechanical bonding in catenanes and rotaxanes: isomerism, modification, catalysis and molecular machines for synthesis (open access)
E. A Neal, S. M. Goldup,* Chem. Commun. 2014, 50, 5128.

Chemical Consequences of Mechanical Bonding

Invited Feature Article for the Chem. Commun. Emerging Investigator Edition, 2014

 

23. Synthesis of a Rotaxane Cu(I) Triazolide under Aqueous Conditions (open access)
J. Winn, A. Pinczewska, S. M. Goldup,* J. Am. Chem. Soc. 2013, 135, 13318.

Rotaxane Triazolide

 

22. Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy
A. I. McIntosh, B. Yang,S. M. Goldup, M. Watkinson, R. S. Donnan,* Chem. Phys. Lett. 2013558, 104.

Crystallization of Lactose

 

21. Terahertz spectroscopy: a powerful new tool for the chemical sciences?
A. I. McIntosh, B. Yang, S. M. Goldup, M. Watkinson, R. S. Donnan,* Chem. Soc. Rev. 201241, 2072.


THz

 

20. Macrocycle Size Matters: “Small” Functionalized Rotaxanes in Excellent Yield Using the CuAAC Active Template Approach
H. Lahlali, K. Jobe, M. Watkinson, S. M. Goldup,* Angew. Chem. Int. Ed. 201150, 4151.

Size Matters
Highlighted as Synfact of the Month, June 2011 (Synfacts, 2011, 7, 725)

 

19. Two Flavors of PEPPSI-IPr: Activation and Diffusion Control in a Single NHC-Ligated Pd Catalyst?
I. Larrosa,* C. Somoza, A. Banquy, S. M. Goldup,* Org. Lett. 201113, 146.

PEPPSI

 

18. Modular ‘Click’ Sensors for Zinc and their Application in vivo
K. Jobe, C. H. Brennan, M. Motevalli, S. M. Goldup,* M. Watkinson,* Chem. Commun. 201147, 6036.

Click Sensor

 

17. Unusual Mechanistic Course of Some NHC-Mediated Transesterifications
S. M. Goldup,* T. Papalia, A. M. Z. Slawin, L. Pignataro,* Org. Lett. 200911, 1643.

NHC esterification


Doctoral and Postdoctoral Publications

16. An autonomous chemically fuelled small-molecule motor
M. R. Wilson, J. Solŕ, A. Carlone, S. M. Goldup, N. Lebrasseur, D. A. Leigh* Nature 2016534, 235.


15. Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine
B. Lewandowski, G. De Bo, J. W. Ward, M. Papmeyer, S. Kuschel, M. J. Aldegunde, P. M. E. Gramlich, D. Heckmann, S. M. Goldup, D. M. D’Souza, A. E. Fernandes, D. A. Leigh,* Science 2013339, 189.

active template knot

Highlighted in multiple news sources including Nature News, Chemical and Engineering NewsChemistry Worldthe BBC and the New Scientist.
For a cartoon video of the machine in action click here.

 

14. A Three-Compartment Chemically-Driven Molecular Information Ratchet
A. Carlone, S. M. Goldup, N. Lebrasseur, D. A. Leigh,* A. Wilson, J. Am. Chem. Soc. 2012134, 8321.

active template knot

Highlighted in by Eva Gabel in "Spotlight on Recent JACS Papers" (J. Am. Chem. Soc. 2012, 134, 9830.)

 

13. Active-Metal Template Synthesis of a Molecular Trefoil Knot
P. E. Barran, H. L. Cole, S. M. Goldup, D. A. Leigh,* P. R. McGonigal, M. D. Symes, J. Wu, M. Zengerle, Angew. Chem. Int. Ed. 201150, 12280.

active template knot

Angewandte Very Important Paper and Cover article
Highlighted by Frédéric Coutrot in Angew. Chem. Int. Ed. 2012, 51, 2544.

 

12. Ligand-Assisted Nickel-Catalysed sp3-sp3 Homocoupling of Unactivated Alkyl Bromides and its Application to the Active Template Synthesis of Rotaxanes
S. M. Goldup, D. A. Leigh,* R. T. McBurney, P. R. McGonigal, A. Plant, Chem. Sci. 20101, 383.

active template Ni sp3 coupling

 

11. An Unusual Nickel-Copper-Mediated Alkyne Homocoupling Reaction for the Active-Template Synthesis of [2]Rotaxanes
J. D. Crowley, S. M. Goldup, N. G. Gowans, D. A. Leigh,* V. E. Ronaldson, A. M. Z. Slawin, J. Am. Chem. Soc. 2010132, 6243.

active template Ni-Cu-mediated sp coupling

 

10. Two Axles Threaded Using a Single Template Site: Active Metal Template Macrobicyclic [3]Rotaxanes
S. M. Goldup, D. A. Leigh,* P. M. McGonnigal, V. E. Ronaldson, A. M. Z. Slawin, J. Am. Chem. Soc. 2010132, 315.

active template [3]rotaxanes

Highlighted in Synfacts 2010, 3, 301.

 

9. Active Metal Template Synthesis of [2]Catenanes
S. M. Goldup, D. A. Leigh,* T. Long, P. R. McGonigal, M. D. Symes, J. Wu, J. Am. Chem. Soc. 2009131, 15924.

active template catenanes

 

8. Active Metal Template Synthesis of Rotaxanes, Catenanes and Molecular Shuttles
J. D. Crowley, S. M. Goldup,* A.-L. Lee, D. A. Leigh, R. T. McBurney, Chem. Soc. Rev. 2009, 1530.

active template oxidative Heck

 

7. Gold(I) Catenane and Rotaxane Synthesis
S. M. Goldup, D. A. Leigh,* P. J. Lusby, R. T. McBurney, A. M. Z. Slawin, Angew. Chem. Int. Ed. 200847, 6999.

1D passive template

Cover article

 

6. Cadiot-Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions
J. Berná, S. M. Goldup, A.-L. Lee, D. A. Leigh,* M. D. Symes, G. Teobaldi, F. Zerbeto, Angew Chem. Int. Ed. 200847, 4392.

active template cadiot

 

5. Active Template Synthesis of Rotaxanes and Molecular Shuttles with Switchable Dynamics via Four-Component Pd(II)-Catalyzed Michael Additions
S. M. Goldup, D. A. Leigh,* P. J. Lusby, R. T. McBurney, Angew. Chem. Int. Ed. 200847, 3381.

active template michael addition

 

4. A Chemically-Driven Molecular Information Ratchet
M. Alvarez-Pérez, S. M. Goldup, D. A. Leigh,* A. M. Z. Slawin, J. Am. Chem. Soc. 2008130, 1836.

chemicall driven molecular information rathet

Highlighted in Science News, 2008, 173, 120.

 

3. A Catalytic ‘Active-Metal’ Template Strategy to [2]Rotaxanes, [3]Rotaxanes and Molecular Shuttles and Some Observations on the Mechanism of the Cu(I)-Catalyzed Azide-Alkyne 1,3-Cycloaddition
V. Aucagne, J. Berná, J. D. Crowley, S. M. Goldup, K. D. Hänni, D. A. Leigh,* P. J. Lusby, V. E. Ronaldson, A. M. Z. Slawin, A. Viterisi, D. B. Walker, J. Am. Chem. Soc. 2007129, 11950.

active template CuAAC

 

2. A Catalytic Palladium Active-Metal Template Pathway to [2]Rotaxanes
J. Berna, J. D. Crowley, S. M. Goldup, K. D. Hänni, A.-L. Lee, D. A. Leigh,* Angew. Chem. Int. Ed.2007, 46, 5709.

active template Pd-mediate sp-sp

Highlighted in Synfacts, 2007, 11, 1158.

 

1. A Simple, Short, and Flexible Synthesis of Viridiofungin Derivatives
S. M. Goldup, C. J. Pilkington, A. J. P. White, A. Burton, A. G. M. Barrett,* J. Org. Chem. 200671, 6185.

viridiofungins